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The HBsAg protein is released from the yeast cells by mechanical cell disruption and detergent extraction, and purified by a series of physical and chemical methods, which includes ion and hydrophobic chromatography, and diafiltration. The purified protein is treated in phosphate buffer with formaldehyde and then coprecipitated with alum (potassium aluminum sulfate) to form bulk vaccine adjuvanted with amorphous aluminum hydroxyphosphate sulfate. The vaccine contains no detectable yeast DNA, and 1% or less of the protein is of yeast origin.S using testosterone ical and call your doctor at once if you have any of these serious side effects:vaginal yeast infection,

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heart disease, angina, a history of heart attack, irregular heart beats, or other heart problems DRUG INTERACTIONS: See also the How to Use section. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, s or change the dosage of any medicine before checking with them first. This drug should not be used with the following medications because very serious interactions may occur: bosentan, coal tar, live vaccines, tacrolimus. If you are currently using any of these medications, tell your doctor or pharmacist before starting cyclosporine. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: birth control pills, caspofungin, ezetimibe, drugs that worsen kidney problems (e.g., acyclovir, aminoglycoside antibiotics including tobramycin; amphotericin B; colchicine; fibrates including fenofibrate; melphalan; NSAIDs including diclofenac and sulindac; ranitidine; sulfa drugs including sulfamethoxazole; vancomycin), drugs affecting liver enzymes that remove cyclosporine from your system (such as allopurinol; amiodarone; azole antifungals including fluconazole and ketoconazole; barbiturates including phenobarbital; bromocriptine; calcium channel blockers including diltiazem, nicardipine, and verapamil; cimetidine; HIV protease inhibitors including indinavir; imatinib; macrolide antibiotics including erythromycin; certain man-made male hormones such as danazol and methyltestosterone; methylprednisolone; metoclopramide; metronidazole; nafcillin; nefazodone; octreotide; quinupristin/dalfopristin; rifamycins including rifampin; certain anti-seizure drugs including carbamazepine and phenytoin; St. Johns wort; ticlopidine), nifedipine, orlistat, sulfinpyrazone, temsirolimus, terbinafine, drugs that may increase potassium levels (e.g., ACE inhibitors including lisinopril, ARBs including losartan, potassium supplements, "water pill" including amiloride, spironolactone). This medication can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include aliskiren, digoxin, dronedarone, eoside, repaglinide, tolterodine, certain statins (atorvastatin, lovastatin, rosuvastatin, simvastatin), other immunosuppressants (such as azathioprine, methotrexate, sirolimus), among others. Do not use potassium-containing salt substitutes while taking this medication. Consult your doctor or pharmacist for more information. This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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