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Studies in vitro have shown that sildenafil is selective for PDE5. Its effect is more potent on PDE5 than on other known phosphodiesterases (10-fold for PDE6, >80-fold for PDE1, >700-fold for PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11). Sildenafil is approximately 4,000-fold more selective for PDE5 compared to PDE3. PDE3 is involved in control of cardiac contractility. Sildenafil is only about 10-fold as potent for PDE5 compared to PDE6, an enzyme found in the retina which is involved in the phototransduction pathway of the retina. This lower selectivity is thought to be the basis for abnormalities related to color vision [see Clinical Pharmacology (12.2)]. cialis canada pharmacy online

5) Michael Douglas: Back in 2005, Douglas shared his praise for the blue pill for helping bridge the 25-year age gap with his wife, Catherine Zeta-Jones. "God bless her that she likes older guys," he told the Daily Mail. "And some wonderful enhancements have happened in the last few years—Viagra, Cialis—that can make us all feel younger," he said. The couple would split in 2013 but have been spotted together on multiple occassions sparking reconciliation rumors. Douglas has even been caught wearing his wedding ring.

cialis india The primary efficacy endpoint in the two studies that evaluated the effect of Cialis for the signs and symptoms of BPH was the International Prostate Symptom Score (IPSS), a four week recall questionnaire that was administered at the beginning and end of a placebo run-in period and subsequently at follow-up visits after randomization. The IPSS assesses the severity of irritative (frequency, urgency, nocturia) and obstructive symptoms (incomplete emptying, stopping and starting, weak stream, and pushing or straining), with scores ranging from 0 to 35; higher numeric scores representing greater severity. Maximum urinary flow rate (Qmax), an objective measure of urine flow, was assessed as a secondary efficacy endpoint in Study J and as a safety endpoint in Study K. GENERIC CIALIS

stomach upset Some men can only take a low dose of Cialis or may have to take it less often, because of medical conditions or medicines they take. generic levitra reviews Be aware that some recreational drugs, such as amyl nitrate or nitrite ("poppers") contain nitrates. Blood pressure can drop when Viagra is taken with alpha-blockers.

In the third doxazosin study, healthy subjects (N=45 treated; 37 completed) received 28 days of once per day dosing of tadalafil 5 mg or placebo in a two-period crossover design. After 7 days, doxazosin was initiated at 1 mg and titrated up to 4 mg daily over the last 21 days of each period (7 days on 1 mg; 7 days of 2 mg; 7 days of 4 mg doxazosin). The results are shown in Table 7. Upset stomach

Change from Baseline to Week 12b 318 -3.8 317 -5.2 -1.4 .001 buy cheap cialis online This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details...Study Fa

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